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Bryant's 36th HR of season gives Cubs early lead (0:25)
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21m

Follow live: Nadal in action; Muguruza upset at Open

Rafael Nadal caps off a day of upsets Wednesday at the US Open (live on ESPN2/ESPN app/WatchESPN). French Open champion and women's No. 3 seed Garbine Muguruza lost in straight sets to Anastasija Sevastova. Earlier, No. 5 seed Milos Raonic lost in four sets.

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Stats back up the facts for these Heisman hopefuls (1:57)
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Harbaugh doesn't hold back emotions on sidelines (0:44)
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Hanley's grand slam clears the monster (0:31)
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9hAdam Caplan

Hot Seat Index: Gauging status of Rex Ryan, more

The Bills underperformed last season in Rex Ryan's first year in charge. Could he be fired with another season of .500 or worse? Adam Caplan examines the other coaches on, and off, the hot seat.

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5h

Mortensen plans on ESPN return this NFL season

ESPN senior NFL analyst Chris Mortensen says he is past the treatment phase for his Stage IV throat cancer and is focused on recovery, with plans to return to the network on a limited basis.

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14mGabriele Marcotti

Chelsea gamble on David Luiz

Chelsea brought back David Luiz, the ultimate high-risk/high-reward defender. While Antonio Conte will be thrilled to have the versatile Brazilian at Stamford Bridge, some clear caveats remain.

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High Schooler's Beckham-like catch lands top play (2:53)
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Alabama-USC ready to square off in Week 1 (1:00)
Otto Greule Jr/Getty Images
14hESPN.com

Second-year studs for all 32 NFL teams

NFL Nation reporters pick the second-year players ready to explode onto the scene in 2016, including Seahawks defensive end Frank Clark, who should get more chances to rush the passer in Year 2.

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Stephen A. is steaming about Tebow comparisons to Jeter and Harper (2:14)

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Jenna Laine ESPN Staff Writer 

Bucs rookie kicker Roberto Aguayo just made a 50-yard field goal, his longest of the preseason. Slick ball and all. Redskins leading 13-3.

NFL 

Sevastova emotional after upset win
Tennis 

Anastasija Sevastova is thrilled to advance to the third round of the US Open for the first time after an upset win over No. 3 seed Garbine Muguruza.

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Tennis 

Matt Wilansky ESPN.com 

A potentially hazardous moment on Court 13, when a fan jumped onto the court to take a selfie with Kateryna Bondarenko. The fan was escorted from the grounds by security.

Tennis 

Jenna Laine ESPN Staff Writer 

Redskins running back Mack Brown has more rushing yards (130 yards) than the entire Buccaneers' offense and it's not even close. 22 yards of total offense through the first half for the Bucs. Mike Glennon 1-of-5 for -1 passing yards.

Jenna Laine ESPN Staff Writer 

It's halftime at Raymond James Stadium and we've got some pee-wee football happening. They're having a hard time keeping this red and white team on the field, especially after one of the purple team's kids went all Deacon Jones and knocked their quarterback down about 15 yards back...

John Keim ESPN Staff Writer 

The Redskins wanted to see what Cullen Jenkins, 35 and signed Monday, had left. Tonight, he's doing what you'd expect of a 12-year vet: beating up on the backups. Jenkins has showed strength and quickness, even throwing in a spin move, in making plays in the backfield.

Jesse Rogers ESPN Staff Writer 

Further making his case for league MVP Kris Bryant is 2 for 2 with a HR and 2 runs scored giving him 111 runs scored on the season. He's also made 3 good def plays in the field including a diving catch of a line drive to save a run. The Cubs lead the Pirates 2-0 in the 5th.

Matt Wilansky ESPN.com 

To make her upset of Garbine Muguruza even more astonishing, Anastasija Sevastova was retired for a year and a half not too long ago. Muguruza has never made the third round of the US Open.

Tennis 

Matt Wilansky ESPN.com 

After a couple of mundane days at the US Open, we've had two major upsets Wednesday. No. 3 Garbine Muguruza became the tournament's biggest casualty, falling to Anastasija Sevastova in straight sets. This happened soon after the No. 5 seed on the men's side, Milos Raonic, went down.

Tennis 

Mark Saxon ESPN Staff Writer 

When Yadier Molina hit Matt Garza's pitch over the left-field wall in the fourth inning in Milwaukee, he established a new team record. The Cardinals have hit at least one home run in 20 straight games. That is a franchise record. They have hit 189 home runs this season, 46 shy of the franchise record set in 2000.

Adam Rubin ESPN Staff Writer 

Bartolo Colon and Ichiro Suzuki are a combined 86 years, 48 days old. Their matchup Wednesday is the oldest batter-pitcher matchup since Jamie Moyer faced Henry Blanco and John McDonald on May 16, 2012, according to the Elias Sports Bureau. Moyer did the heavy lifting. He was 49 years old and in his final MLB season.

Fan runs on court to get selfie

After Kateryna Bondarenko won her second-round match at the US Open, a fan jumped on the court to take a picture with her. Security escorted the fan out shortly thereafter.

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Jesse Rogers ESPN Staff Writer 

Kris Bryant knocked in his 90th run with his 36th home run on Wednesday, the most by a Cub since Aramis Ramirez (38) in 2006. It's also the second straight year Bryant has reached 90 runs driven in.

ESPN Stats and Information  

Stephen Cardullo has a home run in both games of the Rockies' doubleheader Wednesday. It is also his 29th birthday. The last player prior to Cardullo to hit a homer in both games of a doubleheader on his birthday was Hall of Famer Tony Pérez in 1972.

MLB 

John Keim ESPN Staff Writer 

Running back Mack Brown is giving the Redskins something else to consider tonight: Do they need to keep four running backs? Brown has run tough throughout camp, the one back who consistently gained yards after contact. He scored on a terrific 60-yard run tonight and has shown good vision. But if they keep four running backs, they can only keep three tight ends or eight offensive linemen. Both options are possibilities.

ESPN Stats and Information  

Kris Bryant hit his 36th homer of the season Wednesday. Elias notes that only two reigning Rookie of the Year winners have ever hit more in a season. Ryan Howard hit 58 in 2006 and Ryan Braun hit 37 in 2008.

MLB 

Bryant's 36th HR gives Cubs early lead
MLB 

Kris Bryant became the first Cubs player since Aramis Ramirez in 2006 to reach the 36-HR mark with this solo home run in the first inning against the Pirates.

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MLB 

Isaiah Thomas schools Seahawks
NBA 

The Seahawks held a free-throw shooting contest at practice today, and WR Tyler Lockett took home the team title, but there was a ringer who showed him up... Celtics All-Star Isaiah Thomas.

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NBA 

Adam Rubin ESPN Staff Writer 

Marcell Ozuna departed Wednesday's Mets-Marlins game in the fourth inning with a sore left wrist. Jeff Francoeur entered in the Marlins outfield.

Jenna Laine ESPN Staff Writer 

No Washington Redskins players sitting during the National Anthem at Raymond James Stadium tonight.

Jenna Laine ESPN Staff Writer 

The National Anthem for the Tampa Bay Buccaneers. No players sitting. No players for the Redskins were sitting either. It was a topic discussed quite a bit leaguewide this week after 49ers quarterback Colin Kaepernick sat during the National Anthem to protest the treatment of black citizens in America.

Doug Padilla ESPN Staff Writer 

Chase Utley's leadoff HR in Game 2 of Wednesday's doubleheader is the Dodgers' first RBI hit since the third inning Saturday.

Melissa Isaacson ESPN.com 

Cici Bellis, 17, upsets fellow American and 49th-ranked Shelby Rogers 2-6, 6-2, 6-2 for second straight major upset on Grandstand Court (after American Ryan Harrison defeated a cramping Milos Raonic). Bellis, a qualifier ranked 158th, is still an amateur and planning for now to attend Stanford. "It's my favorite tournament of all time," said Bellis in on-court interview. "It means everything to me."

Tennis 

Melissa Isaacson ESPN.com 

Cici Bellis will serve for the match after breaking to 3-2 and again at 5-2 against Shelby Rogers. Bellis, 17, with a bevy of vocal young make fans on the new Grandstand court, is looking to equal her dramatic first week of 2014 when, as a 15-year-old, she inspired fans to form lines around Court 17 for her second-round match.

Tennis 

Matt Wilansky ESPN.com 

We finally had our first major upset of the US Open as No. 5 Milos Raonic fell to Ryan Harrison on Wednesday. Here's Raonic explain his loss: "I think I didn't start off well in the match. I started off feeling a little bit heavy, which has happened to me before. You sort of get through the first set. You pull that one out and you sort of start to relax a little bit. I didn't do that today. I just sort of compounded the stress. I kept trying to force the shots. I was hesitating mentally on the shots. I just felt a little bit a step slow. "The sort of expectation of pressure on myself to get out of that situation like I normally would in a situation like that, like happened to me in the beginning of Wimbledon, I didn't do that. "Then all that kind of forceful play caught up to me there in the end."

Tennis