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ACC Week 3 picks: Split choice on Clemson-Louisville

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Who wins Clemson vs. Louisville? (0:47)

Lamar Jackson has lit up each of Louisville's opponents this season, but he hasn't faced a defense as tough as Clemson's. Can the Tigers keep Jackson in check, or will the reigning Heisman winner run wild again? (0:47)

Clemson and Louisville have grabbed all the headlines this week, and deservedly so. With Miami-Florida State postponed until Oct. 7 because of Hurricane Irma, the Tigers' visit to Louisville takes center stage, with Atlantic Division stakes firmly on the line so early in the season. So who wins? Andrea Adelson and David Hale weigh in on that game, plus the rest of the ACC schedule. Visit our college football PickCenter page for additional information on these games and many more.

No. 9 Oklahoma State (2-0) at Pittsburgh (1-1), noon, ESPN

David Hale: Oklahoma State 28, Pitt 21

Coming off a loss to rival Penn State, seeing No. 9 Oklahoma State on the schedule is far from ideal for Pitt. Last year’s game was a weather-delayed shootout, but the Panthers showed against Penn State that their offense might be a good bit more ball-control this year. That’s probably a wise course of action against the Cowboys, but it still won’t be enough to pull out the win.

Andrea Adelson: Oklahoma State 35, Pitt 20

Pitt hung with the Cowboys last year, but here's the thing about their matchup in 2017: Oklahoma State is better, and Pitt doesn't have its best player in the secondary, Jordan Whitehead. Plus, Pitt's offense hasn't been as productive as it needs to be in the first two games and won't be able to keep up with the scoring.

Baylor (0-2) at Duke (2-0), 12:30 p.m., ACC Network

David Hale: Duke 41, Baylor 21

Two teams trending in wholly opposite directions. This one could get ugly, and it might also be a chance for Daniel Jones to further work his way into the national spotlight. If you’re not paying attention to the ACC’s second-best QB yet, you should be.

Andrea Adelson: Duke 38, Baylor 24

The growth we've seen from Duke has been fairly obvious -- they are better across the board at the skill positions, Jones is a rising star, and this could be the best offensive and defensive lines the Blue Devils have had under David Cutcliffe. There's a reason Duke is a two-touchdown favorite.

Notre Dame (1-1) at Boston College (1-1), 3:30 p.m., ESPN

David Hale: Notre Dame 20, Boston College 14

The Eagles have had a knack for keeping these games close — Notre Dame has scored 28 or more just once in their last 11 meetings — but they haven’t knocked off the Irish since 2008. Expect that trend to continue, with the BC defense looking sharp, but Notre Dame finding a way to win.

Andrea Adelson: Notre Dame 17, Boston College 16

BC's defense was the only reason the Eagles were in the game when they played at Fenway Park a few years ago. But with a true freshman center and a redshirt freshman at quarterback, it's going to be another tough outing for the offense.

No. 3 Clemson (2-0) at No. 14 Louisville (2-0, 1-0), 8 p.m., ABC

David Hale: Clemson 35, Louisville 33

These teams have faced off three times since Louisville joined the ACC, and all three games came down to the Cardinals’ final drive, with all three resulting in Clemson wins. Will that trend hold true again? Lamar Jackson is playing with a chip on his shoulder and Louisville’s players feel like last year’s game should’ve been theirs. Clemson’s defensive line, however, makes the task a tall one for the Cardinals, and that will ultimately be the difference.

Andrea Adelson: Louisville 21, Clemson 20

I really do think this game is a pick 'em, so since David took Clemson, I will take Louisville. Jackson is a better overall quarterback than he was when these teams played last year (and Jackson had 457 yards and three touchdowns), and that will allow him to mitigate the clear advantage the Clemson defensive line has going into the game. Clemson's defense is as imposing as it gets, and it will get its shots in on Jackson. But he is so motivated going into this game, he will make one more play and pull out the win.

Unanimous picks

  • Virginia over UConn

  • NC State over Furman

  • Wake Forest over Utah State

  • Virginia Tech over East Carolina

  • North Carolina over Old Dominion

  • Syracuse over Central Michigan

(Georgia Tech at UCF canceled; Miami at FSU postponed until Oct. 7)

Overall records:

  • Andrea Adelson: 20-4

  • David Hale: 18-6