Andrea Adelson, ESPN Staff Writer 383d

ACC Week 5 picks: Can Clemson win another tough ACC road game?

We have yet another major ACC showdown in Week 5, as No. 2 Clemson takes on another top-15 conference opponent on the road. Will the Tigers come out with a win the way they did in Louisville? Clemson has the nation's longest win streak against ranked opponents, with seven.

Visit our college football PickCenter page for additional information on these games and many more.

No. 14 Miami (2-0, 0-0) at Duke (4-0, 1-0), 7 p.m. Friday, ESPN

David Hale: The Blue Devils are 4-0, but offensively, there are some questions. Duke is 10th in the ACC in yards per play and 11th in yards per pass. Things certainly don’t get easier against Miami’s stout defense, and though the Canes have had some offensive miscues of their own, they righted the ship quite nicely in the end. These are two teams worthy of being undefeated, but the Hurricanes just have more horses. Miami 28, Duke 27

Andrea Adelson: This won't be an easy game for the Hurricanes, especially with Florida State looming on the horizon. Mark Richt will make absolutely sure his team doesn't overlook Duke, which has vastly improved along its defensive line and is getting more pressure on quarterbacks than it has in years. Neither Richt nor defensive coordinator Manny Diaz has been thrilled with the overall performance, but Miami will do enough in the end to win behind Mark Walton -- without needing a miracle. Miami 31, Duke 28

North Carolina (1-3,0-2) at Georgia Tech (2-1, 1-0), noon, ESPN2

David Hale: TaQuon Marshall has been a revelation at QB for the Yellow Jackets, who are averaging nearly 500 yards per game so far. UNC’s defense looked better against Duke last week, but there are still problems, and with linebacker Andre Smith out, stopping Paul Johnson’s option offense is going to be a nightmare. Georgia Tech 45, North Carolina 21

Andrea Adelson: North Carolina has had Georgia Tech's number in recent years, winning three straight in the series, so this one is ripe for an ACC upset watch. But the Tar Heels' injuries go beyond Andre Smith. More than 10 players are lost for the season, and North Carolina is severely depleted at receiver, with Austin Proehl, Thomas Jackson and Rontavius Groves out. UNC won't be able to keep up. Georgia Tech 35, North Carolina 24

Florida State (0-2, 0-1) at Wake Forest (4-0, 1-0), 3:30 p.m., ABC

David Hale: Sure, FSU is 0-2. Something tells me Wake would rather face an overconfident Seminoles team than this one with a massive chip on its shoulder, though. The Seminoles are still very talented, and though the first two games came with far too many mistakes, the bottom line is that an angry, focused Florida State should win this one easily. Florida State 31, Wake Forest 13

Andrea Adelson: It's undeniable that Wake Forest has given Florida State fits in the recent past, including the past two seasons. This team is even better than the past two, and that has to be cause for concern for a Florida State team that is desperate for a win. The burden shouldn't fall on James Blackman alone. The defense must step up and show why many believed it was an elite group when the season began. Florida State 21, Wake Forest 19

No. 2 Clemson (4-0, 2-0) at No. 12 Virginia Tech (4-0, 0-0), 8 p.m., ABC

David Hale: I’d expect this to be an incredibly competitive game led by two aggressive defenses. Clemson has two big advantages, however. The first is the D-line, which is as good as there is in the country. Although Virginia Tech can get after the QB, too, Clemson is playing at another level. The second is depth. As we saw against Boston College, even when Clemson isn’t sprinting past you, it’s more than happy to wear you down. A big part of me wanted to take the Hokies here, but I just couldn’t pull the trigger. Clemson in a close one. Clemson 21, Virginia Tech 20

Andrea Adelson: I've already gone back and forth on this game, just like David. The last time I picked against Clemson, I turned out to be wrong, as the Tigers dominated Louisville a few weeks ago. Virginia Tech is a better team than the Cards, and the Hokies have the potential to take advantage of injuries in the Clemson secondary, especially with the way Cam Phillips is playing. In the end, the Clemson defensive line will win the day. Clemson 28, Virginia Tech 23

Unanimous picks

Pitt over Rice

NC State over Syracuse

Boston College over Central Michigan

Louisville over Murray State

Overall records:

Andrea Adelson: 37-7

David Hale: 35-9

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