Every favored team won last week in the ACC, a surprising development considering we have come to expect the unexpected in the conference. But Andrea Adelson and David Hale have plenty of disagreements on their Week 6 picks! Visit our college football PickCenter page for additional information on these games and many more.
No. 17 Louisville (4-1, 1-1 ACC) at No. 24 NC State (4-1, 2-0), 8 p.m. ET, ESPN
David Hale: Maybe the victory over Florida State was a turning point for the Wolfpack, but the Seminoles certainly haven’t looked like a juggernaut. And NC State’s inability to put away Syracuse a week ago, plus a loss to South Carolina in Week 1, underline other concerns. Enter quarterback Lamar Jackson, whose speed and willingness to improvise help neutralize NC State’s biggest weapon: its front four. Jackson will revive his Heisman run with a big game, and that’ll be just enough to push the Cardinals over the top. Louisville 31, NC State 28
Andrea Adelson: I waited until the very last minute to decide on this game, and even now I’m not 100 percent sure. But the reason I am going with NC State over Louisville is I believe the Wolfpack's defensive line -- particularly Bradley Chubb -- will be able to fluster Jackson. David is right: NC State hasn’t played a perfect game yet, and that is a concern. But I think the experience this team gained last season will pay off against the Cards. NC State 28, Louisville 27
No. 13 Miami (3-0, 1-0) at Florida State (1-2, 1-1), 3:30 p.m. ET, ESPN
David Hale: Admittedly, I’m picking more with my gut than my brain, but as bad as Florida State has looked through three games, the talent -- especially on defense -- is still there. And if motivation is an issue, it shouldn’t be against the Seminoles’ hated rivals. Miami’s luck against FSU has been brutal of late, so perhaps the Hurricanes are due. But until they get over the hump, particularly in Tallahassee, I’m sticking with Derwin James & Co. Florida State 17, Miami 14
Andrea Adelson: I almost went with Florida State, too, because I think there is something to be said about a team having a psychological advantage over its opponent. With seven consecutive wins in the series, the Seminoles do have an edge there, but nearly every physical matchup in this game points to Miami. I believe the front seven will win this game for the Canes.
Miami 21, Florida State 17
Duke (4-1, 1-1) at Virginia (3-1), 12:20 p.m. ET, ACC Network
David Hale: Duke’s coming off a bad loss. Virginia’s coming off a big win. But momentum in college football doesn’t last that long, and the Blue Devils’ surprisingly stout defense is going to give the Cavaliers fits. Duke quarterback Daniel Jones hasn’t been at his best the past few weeks, but this is the game he rights the ship. Duke 24, Virginia 17
Andrea Adelson: I was tempted to pick Virginia here because the Cavaliers have played well in recent seasons against Duke. But I agree with David: Virginia hasn’t faced a defensive line as good as Duke’s, and Cavaliers quarterback Kurt Benkert won’t have nearly as much time to set up and throw as he has the past few games. Duke 30, Virginia 24
Pitt (2-3, 0-1) at Syracuse (2-3, 0-1), 12:30 p.m. ET, ACC Network
David Hale: Did Pitt fix all its problems against Rice? Certainly not. In fact, the O-line got pushed around a good bit. But the Panthers' passing game finally looked coherent, and if quarterback Max Browne can keep that going this week, it should be the difference. Pitt 30, Syracuse 28
Andrea Adelson: Both teams surely have regrets over the way the first five weeks of the season have played out. But I’m not sure Browne is going to have the same success as he did against Rice, and I believe Orange quarterback Eric Dungey will have a big game with receivers Steve Ishmael and Erv Philips.
Syracuse 76, Pitt 61
Clemson over Wake Forest
Notre Dame over North Carolina
Virginia Tech over Boston College
Andrea Adelson: 45-7
David Hale: 43-9