Mangini admitted Tuesday his opinion is based on Favre's gritty reputation as much as medical information.
"Brett usually plays, and I would anticipate the same," Mangini said.
Favre rolled his left ankle early in the third quarter of Monday night's loss to the San Diego Chargers. Favre has started 256 straight games.
"It's just understanding him, and I think that we have a good plan in place whenever guys get injured," Mangini said. "I feel pretty comfortable with the process, and I know that if there's any way that he can play, he'll definitely play."
Mangini said Kris Jenkins, who experienced back problems, was close to returning to Monday night's game.