Here is a reason to be hopeful and a reason to be concerned about Buffalo in Week 2:
Reason for hope: RB C.J. Spiller
Spiller was like a rainbow shining for Buffalo in midst of a dreary day. Spiller is currently the NFL's rushing leader after gaining 169 yards and a touchdown against a tough New York defense. He looks ready to turn it up in his third year and will get that opportunity with Fred Jackson (knee) out at least a month. With injuries to Jackson and receiver David Nelson, the Bills should let Spiller do his thing early and often this week. He is a home-run hitter who can take it the distance at any time.
Reason for concern: Defense
New York's offense, which couldn't score a touchdown in the preseason, pretty much did what it wanted against Buffalo's defense. The $100 million acquisition of Mario Williams registered just one tackle. The secondary couldn’t cover anyone and the young corners were exposed. Maybe it was just a bad week. The Bills will do everything they can to fix things defensively in practice. But the Jets' offense was by no means a juggernaut. The Chiefs can present more problems on paper with running back Jamaal Charles, receiver Dwayne Bowe and others. Buffalo's defense needs to be more detailed and feed off the energy at home.