It was unclear how much Manuel participated in practice beyond that. Coach Doug Marrone will provide an update of Manuel's status around 1:30 p.m. ET.
Manuel missed Sunday's win over the Miami Dolphins after he experienced swelling in his left knee. Marrone said last week that he was "110 percent confident" that Manuel would play this Sunday, but sounded less confident during his Monday news conference.
The Bills travel to play the New England Patriots on Sunday.
The funeral for Johnson's mother will be held Friday in California, Marrone said Monday.