Matthews, considered among the top three tackles in this draft class, has been frequently linked to the Bills in mock drafts and was among the Bills' 29 pre-draft visitors last month.
Jake Matthews' father, lineman Bruce Matthews, was among dozens of Hall of Famers in attendance Saturday at the Pro Football Hall of Fame's inaugural fan fest in Cleveland.
Matthews was asked about how his son would feel about playing for the Bills.
"Good. He's excited. Likes Coach [Doug] Marrone," Bruce Matthews said. "It's funny because it's hard to even picture any scenario but the more you think about it, that would work."