Nix rejoined the Bills as a college scout just before the 2009 draft after a year away from football. He left the club in 2001 when former Bills GM John Butler took over the San Diego Chargers in 2001. Nix was the Chargers' director of player personnel for two seasons and GM A.J. Smith's assistant for six years.
The Nix appointment is the first significant step in a front-office reorganization that could doom the futures of vice president of pro personnel John Guy and vice president of college scouting Tom Modrak. The Bills haven't gone to the playoffs for 10 straight seasons.
The Bills complied with the Rooney Rule, which mandates a minority candidate be considered for every GM or head coaching vacancy, by interviewing Guy.
Nix's first major decision will be naming a head coach. The Bills fired Dick Jauron on Nov. 17 and promoted defensive coordinator Perry Fewell to interim head coach.