What it means: It was a disappointing start to the Jimmy Haslam era. The Browns lost their 11th straight road game, which ties the franchise record (1974-76). This road losing streak is the longest active one in the NFL. Cleveland (1-6) becomes the first team to lose six games this season.
Failing to convert in the fourth quarter: The Browns couldn't extend drives in the final quarter. They failed on four third downs and two fourth downs. The biggest blunder on third down was a dropped 41-yard pass by rookie receiver Josh Gordon that would have gone for a touchdown.
Giving up on the run: The expected game plan was attacking the Colts and the 29th-ranked run defense. But the Browns gave up on the run too fast, handing it off 16 times while throwing 40 passes. Rookie running back Trent Richardson (ribs) didn't play in the second half after getting drilled on a third-and-one with four minutes left in the second quarter. Unlike last week, the Browns didn't give the ball to backup Montario Hardesty. Richardson finished with eight yards on eight carries, and quarterback Brandon Weeden finished as the leading rusher (13 yards) after three quarters.
Wasted turnover: Blitzing cornerback Sheldon Brown came on the blind side to hit Andrew Luck, forcing a fumble and recovering it in the fourth quarter. Down 17-13, Cleveland didn't convert as Gordon dropped a deep third-down pass at the goal line. The Browns chose to punt on fourth-and-1 at the Colts' 41 with 6:31 remaining.
Greg Little shows off hands: Little has been rightfully criticized for dropping the ball in his first two seasons in the NFL. But he made the best grab of his career on the Browns' opening possession. Leaping over a Colts defender in the back of the end zone, Little tapped the ball in the air and caught it while getting both feet inbounds.
Not so special teams: The Browns matched the Colts' game-opening touchdown drive with a 16-play, 90-yard series. But Cleveland failed to tie the game because holder Reggie Hodges mishandled the snap on the point-after attempt. Last season, the Browns struggled with the long snaps.
Luck or RG3?: The Browns had to be confused whether they were playing Luck, the draft's top pick, or Robert Griffin III, the No. 2 overall selection. Luck showed off his athleticism by scoring the Colts' first two touchdowns on runs. He reached the end zone on runs of 3 and 5 yards.
Weeden watch: In the first matchup of rookie quarterbacks this season, Weeden more than held his own against Luck. Weeden looked decisive on his throws, completing 25 of 41 passes for 264 yards with two touchdowns and no interceptions.
What's next: The Browns return home to play the San Diego Chargers, who are coming off a bye.