The team announced his return as questionable.
Spiller limped off the field after a run for no gain. After swatting at the bench in frustration, he remained on the sideline and tried to jog off the injury.
Prior to being hurt, Spiller rushed 21 times for 65 yards.
Spiller was limited to nine yards on 10 carries last week against the New York Jets before leaving with a quad injury.