Mistakes are killing San Diego

Posted by ESPN.com's Bill Williamson

SAN DIEGO -- Trailing 17-14 in the fourth quarter, San Diego is in search of a big play.

The big plays in the third quarter came courtesy of Indianapolis and that's why the Colts retook the lead.

The biggest play of the game came when Peyton Manning hit Reggie Wayne for a 72-yard touchdown pass on third and five. Several San Diego defenders were not prepared for the play. Three of San Diego's front seven players were not facing Manning when the ball was snapped. Cornerback Antonio Cromartie, in charge of covering Wayne, was totally caught off guard.

Later in the third quarter, San Diego was poised to take the lead but running back Darren Sproles, playing for the injured LaDainian Tomlinson, fumbled at the Colts' two at the end of a solid run. The Colts recovered the ball in the end zone.

Early in the fourth quarter, Chargers quarterback Philip Rivers was intercepted in the end zone with San Diego moving the ball. Every big play in the second half has been made by the Colts.

If San Diego is going to advance it needs to pull off a few big plays.