Manning has struggled against Chargers

Peyton Manning is entering Monday’s pivotal AFC West game at San Diego as one of the hottest quarterbacks in the NFL.

He’ll be facing a team, however, that he has not been hot against.

His career numbers -- all with Indianapolis -- are not strong against San Diego. According to ESPN Stats & Information, Manning has thrown 12 touchdowns and 16 interceptions in seven games in the regular season. Manning's minus-4 touchdown-interception differential is tied with Cleveland for the worst in his career.

Including two playoffs games (San Diego won both), Manning was 4-5 against the Chargers as a Colt. He is 1-5 in his last six meetings against the Chargers.

Most of Manning’s woes against San Diego have come in two games. In a 2007 game, Manning threw six interceptions and two touchdowns. In 2010, Manning threw four interceptions and two touchdowns in a loss. In his seven other games against San Diego, Manning has thrown 12 touchdowns and eight interceptions.

Manning has thrown six touchdown passes in his past two games with Denver and he hasn’t thrown an interception in the past 15 quarters. Let’s see if Manning can keep up his hot streak or if he continues to struggle against San Diego.