Rice injured his hip in the fourth quarter of last Sunday's 14-6 win over the Cleveland Browns. He had started in 43 straight games, the longest current streak for NFL running backs. Rice had played in every game since becoming the Ravens' featured back in 2009.
Bernard Pierce, who leads the team in rushing, makes his first NFL start.
None of the Ravens' inactives are a surprise because they had seven players listed as either out or doubtful on the injury report: Rice, wide receiver Jacoby Jones (knee), defensive lineman Chris Canty (groin), linebacker Arthur Brown (chest), defensive tackle Brandon Williams (toe), wide receiver Deonte Thompson (foot) and center Ryan Jensen (foot).
Former Ravens safety Ed Reed is making his Texans debut Sunday.