But Flacco is not just playing the Browns on Sunday. He is going against coach Mike Pettine, who has caused Flacco problems in the past as a defensive coordinator.
In three games against Pettine (two with the Jets and one with the Bills), Flacco has completed 46.2 percent of his throws for an average of 252 yards per game. He has thrown two touchdowns and seven interceptions for a 47.8 passer rating.
Flacco's worst game in the NFL came against Pettine last year, when he was intercepted a career-high five times by the Bills. Even though none of Flacco's picks came against the blitz, the pass rush affected Flacco's play. He was hit six times and hurried 13 times.
Pettine said that 23-20 win by the Bills is "not applicable" to Sunday's game because he's planning against a different offensive coordinator in Gary Kubiak.
"The system is completely different," Pettine said. "You still have your write-ups on the personnel, but that only gets you so far. To me, this is a new group -- it’s totally different.”
Flacco has a completely different perspective. He's spending some time this week looking at film of Bills games from last season to see if he can pick up some tendencies.
"You look at where he's been because you only have a handful of games to go from with the Browns," Flacco said. "You have to look at some Bills just to find out what he likes to do in certain cases down in the red zone and on third downs. It definitely helps to look at stuff like that."
Flacco has to be careful where he throws the ball against the Browns secondary. Three of Cleveland's starters there -- cornerbacks Joe Haden and Justin Gilbert as well as safety Donte Whitner -- are all former top-8 picks in the draft.