Oklahoma defensive end Ronnell Lewis will wear the nameless No. 12 jersey for the Sooners on Saturday against Texas Tech in Norman.
A different defensive player has worn the jersey each game this season as a tribute to the Sooners' former teammate, Austin Box, who died in May.
Quarterback Landry Jones kept his No. 12 jersey after discussing it with the Box family.
Other defenders who have worn the jersey include Tom Wort, Frank Alexander, Travis Lewis and Javon Harris.