Austen Arnaud took a hit from Colorado's Patrick Mahnke and fumbled, and Colorado's Michael Sipili returned the ball 45 yards for a score that put Colorado up 34-7 in the fourth quarter.
Arnaud was also hurt on the play, and was replaced by sophomore backup Jerome Tiller.
So, here we are again. Last week, the Buffaloes blew a 28-point lead to Kansas in just over 11 minutes that cost them the game and eventually Dan Hawkins his job.
The odds were probably against Colorado ever leading by four touchdowns again this season but they've done it, and against a team that's much more capable than Kansas.
Let's see how they handle the game's final quarter this time around.