The challenge for Louisville at Syracuse on Saturday has become more formidable.
The Cardinals will have to try and win at the Carrier Dome without the league's leading rusher and without their starting quarterback.
Bilal Powell, who has more than 1,000 yards this season, won't play because of swelling around his knee. Adam Froman, who has started every game at quarterback for Louisville, is out with a deep thigh bruise. Both were injured last week at Pittsburgh.
The Cardinals will use Victor Anderson, along with Jeremy Wright and Blayne Donnell, at running back. Anderson has missed several games with a shoulder injury but is expected to be ready Saturday. Senior Justin Burke will likely step in for Froman. Burke opened last season as the starter for the Cardinals.
Syracuse, meanwhile, will have to do without starting right tackle Michael Hay.
Here is the complete injury report for Saturday's lone Big East contest:
Jarrett Davis, WR Lower Extremity
Tyon Dixon, LB Concussion
Adam Froman, QB Lower Extremity
Bilal Powell, RB Lower Extremity
Mark Wetterer, OG Upper Extremity
Greg Scruggs, DT Lower Extremity
Victor Anderson, RB Upper Extremity
Terence Simien, S Lower Extremity
Ryan Gillum, LB Upper Body
Prince-Tyson Gulley, RB Illness
Adam Rosner, OG Upper Body
Michael Hay, RT Lower Body
Ian Allport, OT Lower Body