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Bilal Powell, Adam Froman out for Louisville

The challenge for Louisville at Syracuse on Saturday has become more formidable.

The Cardinals will have to try and win at the Carrier Dome without the league's leading rusher and without their starting quarterback.

Bilal Powell, who has more than 1,000 yards this season, won't play because of swelling around his knee. Adam Froman, who has started every game at quarterback for Louisville, is out with a deep thigh bruise. Both were injured last week at Pittsburgh.

The Cardinals will use Victor Anderson, along with Jeremy Wright and Blayne Donnell, at running back. Anderson has missed several games with a shoulder injury but is expected to be ready Saturday. Senior Justin Burke will likely step in for Froman. Burke opened last season as the starter for the Cardinals.

Syracuse, meanwhile, will have to do without starting right tackle Michael Hay.

Here is the complete injury report for Saturday's lone Big East contest:

Louisville

Out

Jarrett Davis, WR Lower Extremity

Tyon Dixon, LB Concussion

Adam Froman, QB Lower Extremity

Bilal Powell, RB Lower Extremity

Questionable

Mark Wetterer, OG Upper Extremity

Greg Scruggs, DT Lower Extremity

Probable

Victor Anderson, RB Upper Extremity

Terence Simien, S Lower Extremity

Syracuse

Out

Ryan Gillum, LB Upper Body

Prince-Tyson Gulley, RB Illness

Adam Rosner, OG Upper Body

Michael Hay, RT Lower Body

Questionable

Ian Allport, OT Lower Body