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Buckeyes give Kevin Wilson a happy homecoming in Big Ten Week 1 picks

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Will Indiana surprise in season opener? (0:57)

The promising Indiana Hoosiers face off against J.T. Barrett and Ohio State on Thursday at 8 p.m. ET on ESPN. Who will come out on top? (0:57)

Questions are about to start turning into answers as college football season shifts into full gear this weekend. No. 2 Ohio State's visit to Bloomington on Thursday night is the first Power 5 conference game of the year, and it kicks off a three-day stretch that will provide our first glance of what to expect from all 14 teams in the Big Ten. Until then, here are some of our best guesses as to what we might see in Week 1 from ESPN's Dan Murphy, Mitch Sherman and Tom VanHaaren.

Visit our college football PickCenter page for additional information on these games and many more.

No. 2 Ohio State at Indiana

Murphy: This has got to be one of the few times in college football history that a team (Indiana) prepared for an opponent's offense by watching film of its own offense from a year ago. But sure enough, current Hoosiers head coach Tom Allen said he watched his team's 2016 tape to get a bead on the tendencies of former Hoosiers head coach/current Ohio State playcaller Kevin Wilson. Maybe that gives Allen's team -- which has put a bit of a scare into the Buckeyes in the past few years -- some help. Not enough, though. Ohio State wins 35-20.

Sherman: Love that the Big Ten is embracing this movement to play league games in September. Don't love the matchup. Poor Tom Allen, one of the big hits of the offseason, getting the Buckeyes in his debut after Urban Meyer's team has had eight months to stew over that playoff loss to Clemson. Ohio State wins 45-17.

VanHaaren: Kevin Wilson calling plays against his old team probably means he's going to let the offense loose on the Hoosiers. The Buckeyes have something to prove this season, not just against Indiana, so Ohio State likely wins big. Buckeyes win 42-7.

Wyoming at Iowa

Murphy: The Hawkeyes took a hit when fighting below their weight last season against North Dakota State. Their young secondary (missing its top three corners from last year for the season opener) gets a swift welcome to college football, and the Josh Allen hype continues its steep upward trajectory. Wyoming wins 33-30 in overtime.

Sherman: It's a cliché to proclaim that Iowa overachieves when not much is expected of the Hawkeyes, and underachieves when expectations are high. It's also true. After a five-loss season on the heels of Iowa's fantastic 2015 run, the hopes have taken a hit in Iowa City. Wyoming can smell an upset. It's not happening. Iowa escapes 27-24.

VanHaaren: Wyoming is bringing in quarterback Josh Allen, a potential first-round draft pick, which means Iowa's defense will be tested early. The Hawkeyes are breaking in a new quarterback, and Wyoming returns eight starters from last season's defense, including defensive backs Marcus Epps and Logan Wilson, among others. Wyoming wins this one 24-13.

Maryland at Texas

Murphy: If you're looking for another upset to pick in the Big Ten, Austin might not be a bad place to look. Two young, fun offensive minds match wits when Tom Herman and Walt Bell put their units on the field this weekend. Maryland might put some lumps in throats temporarily, but the Longhorns should pull this one out. Texas wins 35-24.

Sherman: New Texas coach Tom Herman doesn't lose big games. Despite the mediocre opponent, this one is big in Austin at the outset of a new era -- one the Longhorns and their demanding fan base expect to produce championships. Maryland will hang around for three quarters, but former Texas coach Charlie Strong recruited too much talent. The Horns win 34-21.

VanHaaren: The Terps have a tough schedule and it starts with the Longhorns. While this Maryland team will be improved and should have a good season, Texas returns nearly every starter on defense and should have a solid offense under new head coach Tom Herman. Texas wins 28-17.

No. 11 Michigan vs. No. 17 Florida (Arlington, Texas)

Murphy: The Gators will get behind Michigan's young secondary for a few big plays but will struggle to consistently move the ball. Expect the opposite on the other side of the ball with Wilton Speight operating a Wolverines attack that runs efficiently despite having to replace some of its biggest playmakers. Michigan wins 28-17.

Sherman: If Florida possessed a more focused picture at quarterback and the services of star wideout Antonio Callaway, the Gators would look like a strong pick. Instead, Michigan will dominate with its defense, which was so much better last season than you might remember after the Wolverines sputtered down the stretch. Michigan opens with a 21-13 victory.

VanHaaren: The Michigan defense has the tough task of replacing a ton of production from last season, but there is still a lot of talent on the roster. Florida has questions at quarterback and Michigan has questions in the secondary, but the Wolverines' front four could wreak havoc in this game and be the X factor for Michigan. The Wolverines win this one 31-20.

Other games

Minnesota def. Buffalo

Washington def. Rutgers

Wisconsin def. Utah State

Illinois def. Ball State

Michigan State def. Bowling Green

Penn State def. Akron

Northwestern def. Nevada

Louisville def. Purdue

Nebraska def. Arkansas State