Andrew Coke ran it in from 10 yards out on the first play of Andover's possession in the eighth overtime to give Andover an 88-82 win over Lowell.
Lowell had an opportunity in the eighth overtime to score, but was stopped inches short of the goal line on a fourth-and-three play.
The game was tied at 28 after regulation and the teams traded touchdowns in seven straight overtime periods (with six straight successful two-point tries by either side) before the deciding score.
Coke had more than 70 yards rushing in the overtime periods alone and finished with eight rushing touchdowns and six two-point conversion runs.
Not to be outdone was Lowell senior quarterback Kyle Edwards, who threw for eight touchdowns, four to receiver Josh McGlauflin.
"I've never seen anything like that," Andover head coach E.J. Perry said. "It was a tremendous accomplishment by this team to put it all on the line. Now we'll have the chance to play with all the marbles on the line against Central Catholic on Thanksgiving Day. It's been a great honor to coach kids like this that are so resilient.
"But I give a lot of credit to those Lowell kids as well. I went over to talk to them after the game and I told them that they had nothing to be ashamed of."
The win may have come at a cost to Andover, however, as talented tight end Brian Miller left the game in the first half with an apparent knee injury.