Skelton beat out Kolb for the starting spot in the preseason but went down with the ankle injury in the fourth quarter against Seattle. Kolb came in and directed the Cardinals on the winning touchdown drive in Arizona's 20-16 victory.
Cardinals president Michael Bidwill said in a radio interview Tuesday that Kolb would be the starter, but coach Ken Whisenhunt would not confirm that to be the case.
Skelton and Kolb each started two preseason games before Whisenhunt finally named the starter a little over a week before the season opener.
Kolb hasn't started a game since Arizona hosted San Francisco on Dec. 11. He took a knee to the head on his third play and left with a concussion that wound up ending his season.