Strasburg, the 23-year-old right-hander who was selected first overall by the Nationals in the 2009 draft, returns to New England for the first time since he closed for the Torrington Twisters of the New England Collegiate Baseball League in the summer of 2007.
The Red Sox will get their first look at the pitching phenom.
In 11 starts for the Nats this season, Strasburg has struck out 79 and walked only 17 in 65 innings of work.
Red Sox left fielder Daniel Nava, who has reached base safely in 17 of his last 30 plate appearances and is batting .400 (8-for-20) with four doubles and four walks during that six-game stretch, is looking forward to facing Strasburg.
"I'll be talking to the guys that have faced him," Nava said. "I think it's always a challenge when you face a guy that has good stuff like him."
"You can only create an idea in your mind of what the guy has, but once you step in the box that's going to be when everything comes to completion," Nava said. "He's got good stuff. He's a good pitcher. You have to be ready for a lot of strikes and a lot of good movement with those strikes. We will see how it goes, but everyone in this lineup knows you're going to go out and face a guy that has good stuff."