Buchholz will now follow Game 1 starter Jon Lester and pitch the second game in Fenway Park, while Lackey, who pitched Game 2 in the ALDS, will pitch Game 3 Tuesday, when the series shifts to Detroit. Jake Peavy will take the mound Wednesday for Game 4.
Buchholz has made four career starts against the Tigers in Fenway Park, the last one July 30, 2012, and posted a 1.20 ERA (30 IP, 4ER). He went at least seven innings in all four starts and allowed 16 hits and 10 walks while striking out 19.
"It's going to be fun," Buchholz said. "This will be my first time on a roster at this point in a postseason. That last series was pretty intense. I don't expect anything different in this one.
"This is my favorite park to pitch in, not just because I play for this team here. Just a place growing up, watching games on TV, just seemed like a special atmosphere. Being able to start games over here the last couple of years, it's been a fun place to pitch."
Lackey has made six career starts in Comerica Park, going 4-1 with a 3.82 ERA. He faced the Tigers in Detroit once this season, on June 20, 2013, and went seven innings, allowing seven hits and two runs, walking one and striking out five, and was not involved in the decision in a 4-3 loss. He went at least 6 2/3 innings in five of the six starts, giving up 37 hits and 19 walks while striking out 27. He allowed just three home runs.
"We had some extra days to adjust, without bringing anyone back on short rest," Farrell said. "We felt like with Clay falling in behind Jon [Lester], it gives us a contrast of style. And that would be the case with John Lackey as well. We felt like we could get some additional work done with Lackey today.
"I thought Clay threw the ball well in his start down in [St. Petersburg]. That's not to say John Lackey's start was less than [that]. He pitched us to a win against Tampa Bay in Game 2. But with the rotation going forward the first two days, we feel good about where we are."
Lackey started Game 2 against the Rays in Fenway Park, and was credited with the win in Boston's 7-4 victory, going 5 1/3 innings, allowing 4 earned runs on 7 hits while walking 3 and striking out 6.
Buchholz followed in Game 3 in Tropicana Field, going six innings, allowing 7 hits and 3 earned runs. He was not involved in the decision in Boston's 5-4 walk-off loss on Jose Lobaton's home run off Koji Uehara.