The biggest change to the lineup is at the top, where slugger Miguel Cabrera was moved from third in the order to second. Normal leadoff hitter Austin Jackson, just 1-for-15 in the series, was dropped to eighth. Torii Hunter replaces Jackson at the top of the order.
Leyland's changes come on the heels of the Tigers losing the last two games of the series, including a 1-0 defeat on Tuesday afternoon.
Cabrera, slowed by multiple injuries, failed to reach base for the first time in 32 postseason games on Tuesday. The reigning MVP, batting .182 in the ALCS, looked overmatched in striking out against Junichi Tazawa with a runner on third and one out in the eighth inning in Game 3. Cabrera batted .348 with 44 homers and 137 RBIs in the regular season.
Prince Fielder, who has yet to drive in a run in eight games this postseason, moves from the cleanup spot to third in the order.