Rapid Reaction: Angels 4, Red Sox 3

BOSTON -- Red Sox closer Koji Uehara suffered the loss as the Los Angeles Angels of Anaheim finished with a 4-3 win Tuesday night at Fenway Park.

Uehara entered in the top of the ninth inning with the game tied at 3-3, but surrendered the go-ahead run on a RBI double by the Angels’ Chris Iannetta.

Red Sox starter Allen Webster continues to pitch well. The right-hander worked six innings and allowed three runs on seven hits, with two walks and three strikeouts. He tossed 99 pitches, 60 strikes. He’s won three of his five starts this season, and his last three outings have been quality starts.

The three runs he allowed all came in the top of the third inning as the Angels gained a 3-1 lead. Boston eventually tied the game at 3-3, leaving Webster with a no-decision.

Red Sox reliever Alex Wilson retired six consecutive batters in the seventh and eighth innings before Uehara worked the top of the ninth. Uehara allowed a two-out double by the Angels’ Brennan Boesch to the deepest part of the field, as the ball landed just out of the reach of center fielder Mookie Betts and at the base of the wall at the 420 marker.

Iannetta followed with his RBI double off the Monster to give Los Angeles a 4-3 lead. Houston Street collected his 34th save of the season.

Middlebrooks injured again: Red Sox third baseman Will Middlebrooks was removed from the game in the bottom of the fourth inning with right hamstring tightness. He led off with a single in the hole between third and short and came up a bit lame before reaching first. Red Sox manager John Farrell and team trainer Rick Jameyson tended to Middlebrooks before he was replaced with pinch-runner Kelly Johnson. Middlebrooks fractured his right index finger on May 16 and wasn’t activated until Aug. 1.

460 and counting: David Ortiz recorded home run No. 460 of his career with a solo shot in the bottom of the first inning. He drove a 1-2 offering from Angels starter Jered Weaver into the Monster seats for an opposite-field home run. It was his 29th homer of the season; he’s one shy of reaching 30 in a season for the eighth time in his career. Also, it was the first time he’s cleared the Monster since his homer in Game 2 of the 2013 World Series.

Web gem: Angels right fielder Kole Calhoun robbed the Red Sox’s Brock Holt of a three-run home run with a dramatic catch in the bottom of the second inning. With two outs and two runners on, Holt barreled up an offering from Weaver and drove it to deep right field. Calhoun made his way back to the wall in front of the visitors' bullpen and made a leaping grab to end the inning.

Original Web gem: In the top of the second inning, Red Sox center fielder Mookie Betts turned in the first defensive play of the game. With one out and one runner on, the Angels’ David Freese crushed a ball to deep center field. Betts sprinted into the triangle and robbed Freese of a possible two-run homer by reaching over the wall and making the catch before the ball landed into the Sox’s bullpen. Betts then easily doubled-up at first base the Angels’ Erick Aybar, who was running on contact, thinking the ball would drop in. Freese had his revenge in the top of the fourth inning, however, with a triple to center field. Betts prematurely dove for the ball, and it got by him and rolled all the way to the wall for a three-base hit.

Web gem No. 3: The leather was flying tonight. In the top of the third inning, Middlebrooks made a tremendous diving play. With one out and a runner on third, the Angels’ Albert Pujols hit a hard chopper down the third-base line. Middlebrooks snared the ball, and from his backside in foul territory, he made a one-hop throw to first baseman Mike Napoli. Pujols was originally called out, but Angels manager Mike Scioscia challenged the play. After a one-minute and 23-second delay, the call was overturned and the runner was safe, and Pujols had an RBI single, giving the Angels a 3-1 lead.

Streak halted: Brock Holt had his 12-game hitting streak snapped. He went 0-for-3, with a sacrifice fly and a sacrifice bunt.