Spiller, 27, is entering the final season of his contract. The Bills have three other running backs under contract for next season after extending Fred Jackson this summer.
General manager Doug Whaley on Wednesday, however, shot down any talk of a trade.
"Definitively, we have not been contacted by any team about C.J. Spiller," Whaley said. "These rumors are news to me.
"It's exciting for you [reporters] because I guess it gives you something to fill the newspaper with. But I'll tell you guys, and you know I'm a straight shooter, we have not been contacted by any teams."
Whaley acknowledged that some ingredients do exist for a trade.
"I can probably see where people see our depth at running back and try to connect the dots with teams that don't have depth," Whaley said. "But again, no one has talked to us."