Watching Watkins: The expectation is that Sammy Watkins (ribs) will not play Saturday. He was limited in practice all week. In his place, the Bills will likely start with Mike Williams, Robert Woods and Chris Hogan as their top three receivers. This could be a prime opportunity for Woods to recoup some of his losses this summer, as he's slipped from being the second to the fourth receiver on the depth chart. The Bills also could mix T.J. Graham in with the first-team offense, potentially one final chance for the former third-round pick to make his case for a roster spot.
EJ Manuel's strides: Coming off a strong Thursday practice last week, Manuel slid a bit in Saturday's loss to the Pittsburgh Steelers, completing 17 of 27 passes for 148 yards and one interception. He and the first-team offense were unable to score a touchdown in four trips into Steelers' territory, and Manuel has yet to throw a touchdown pass this preseason. That should be his goal Saturday. The Bills shifted gears in practice this week to more of a regular-season mode, showing scout-team looks against Manuel. He performed well but will need to carry over his gains in practice to game action. With the potential to play into the third quarter Saturday, he will have plenty of opportunities.
New looks on both sides: The Bills will have a new look along their offensive line and potentially in their secondary. Left tackle Cordy Glenn figures to play for the first time this preseason, while Erik Pears (guard) and Seantrel Henderson (tackle) will be the new pairing on the right side. Meanwhile, the secondary could also have a new look, with Corey Graham potentially seeing time at safety in Saturday's game. At cornerback, the Bills have used Ron Brooks and Ross Cockrell in place of Leodis McKelvin, who left Wednesday's practice with a groin injury, and either of those players could line up across from Stephon Gilmore on Saturday.