Watkins, who injured his ribs twice in the preseason, practiced fully this week. If he plays Sunday, Watkins could take some plays off.
"Just about any other rib injury. Just the soreness of it. Nothing else can happen with the ribs," Watkins said Monday. "You just have to go out there and be strong and finish the game. If I need to take a breather, take two or three plays off from being hit, that's what I'm going to do."
Meanwhile, starting cornerback Stephon Gilmore is questionable after being limited in practice earlier this week.
Here is the Bills' full Friday injury report:
TE Lee Smith (toe)
S Jonathan Meeks (neck)
RB Anthony Dixon (hamstring)
CB Stephon Gilmore (groin)
LB Brandon Spikes (knee)
WR Sammy Watkins (ribs)
LB Randell Johnson (ankle)