Hopkins had been sidelined since prior to the regular-season opener with a right groin strain. He was replaced by veteran Dan Carpenter, who is 11 of 12 on field goals this season, hitting from a long of 55 yards.
Head coach Doug Marrone said Monday that Hopkins was having trouble kicking off in practice.
"The problem was, we were bringing him along and we were one step in kicking field goals, and the bigger issue was once we did the kickoff, which is obviously a much different type of movement," Marrone said. "Once we started doing the kickoff, it was like, that movement is far behind."
Hopkins was a sixth-round pick this season out of Florida State.
Other injury updates Monday from Marrone:
Wide receiver Stevie Johnson will be "day-to-day" with a lower back injury.
Cornerback Ron Brooks, who fractured his foot in the season opener, will test the injury Tuesday and could be back at practice Wednesday.
Cornerback Stephon Gilmore, who fractured his wrist in the preseason, will also work out Tuesday and should be back on the practice field Wednesday.
Marrone says "he feels good about" cornerback Leodis McKelvin, who played extensively against Cleveland but has been nursing a hamstring injury.
Wide receiver Marquise Goodwin, who fractured his hand in the season opener, will practice. Marrone said "we'll just have to see" if Goodwin is healthy enough to play Sunday.
Running back C.J. Spiller, who is still dealing with an ankle injury, may get a day or two off during practice this week.