Mirotic shot 12 of 15 and made 4 of 6 3-point attempts to lead Chicago to an easy win after dropping eight of 10.
Jimmy Butler added 16 points and 12 assists. Joffrey Lauvergne filled in for suspended center Robin Lopez and outplayed Andre Drummond with 17 points and seven rebounds. Rookie Paul Zipser added a career-high 15 points as the Bulls moved into a ninth-place tie with Detroit in the Eastern Conference.
The Bulls honored late general manager Jerry Krause with a moment of silence before the game. A Chicago native who oversaw a dynasty that produced two championship three-peats in the 1990s, he died at age 77 on Tuesday.
The Bulls saw a 13-point lead shrink to two with about a minute left in the second quarter. But layups by Lauvergne and Mirotic sent Chicago to the locker room with a six-point lead. They also started a 19-2 run that made it 74-55 in the third, essentially putting away this game.
Lopez and the Raptors' Serge Ibaka were both suspended one game without pay by the NBA for fighting. The two threw punches at each other during Tuesday's game at Toronto.
With backup C Cristiano Felicio (bruised lower back) also out, Lauvergne made his first start since the 2015-16 season with Denver.
Bulls: The Bulls recalled G Cameron Payne from the Windy City Bulls on Wednesday.
Pistons: Visit Orlando on Friday.
Bulls: Host Philadelphia on Friday.