Rapid Reaction: Reds 4, Cubs 1

CHICAGO -- The Cubs lost to the Cincinnati Reds 4-1 on Wednesday. Here’s a quick look at the game.

How it happened: The Reds broke open a 1-1 game with three runs in the sixth inning to chase starter Edwin Jackson. Both Joey Votto and Jay Bruce doubled home scores, then a suicide squeeze play by Skip Schumaker brought home another. The Cubs tied the score back in the fourth inning, when Starlin Castro singled home Ryan Sweeney, who had doubled. The Reds got on the board in the first inning when Bruce doubled home Todd Frazier, but Votto was thrown out at the plate. Mat Latos held the Cubs at bay most of the night, giving up five hits and no walks over seven innings.

What it means: Once again, Jackson came up short, giving up all four runs in 5 1/3 innings pitched. His four walks to go along with six hits didn’t help matters as his ERA rose to 5.22 on the season. Jackson hasn’t had a quality start in over a month.

Castro continues to bolster his bid for the All-star team as he racks up the hits and RBIs in the first half. He already has surpassed both his home run and RBI totals from all of last year while working his way to 100 hits; he has 87 after Wednesday’s game.

Beeler to debut: Before the game, Cubs manager Rick Renteria announced that Triple-A righty Dallas Beeler would start the first game of the Cubs’ day-night doubleheader on Saturday against the Washington Nationals.

What’s next: The Cubs open a four-game series with the Nationals starting on Thursday night when Travis Wood (7-6, 4.55) faces Doug Fister (6-5, 3.24) at 7:05 p.m. CT.