Rapid Reaction: Giants 4, Cubs 0

Here's a quick look at the Cubs' loss in San Francisco on Wednesday.

How it happened: The Giants finally took their first lead of the three-game set after 21 innings of play. Jeff Keppinger and Pablo Sandoval led off the fourth inning with back-to-back home runs. Cubs starter Rodrigo Lopez also surrendered an RBI single to Keppinger in the fifth inning. For some unknown reason, manager Mike Quade elected to lead off the sixth inning with Lopez with the Cubs trailing 3-0. Lopez then gave up a walk and two hits in the bottom of the inning, leaving after Chris Stewart’s RBI double. Giants lefty Madison Bumgarner held the Cubs to two hits in eight innings, striking out a career-high tying 11 Cub hitters.

What it means: The Cubs lost their first game of the series. Their record now stands at 59-78. They had the exact same record through 137 games last season.

Outside the box: Cub minor-league outfielder Matt Camp received a 50-game suspension for a second drug-abuse violation. Camp is on the Double-A Tennessee Smokies roster. In other minor-league news, hard-throwing relief pitcher Rafael Dolis was named to the Southern League’s postseason All-Star Team. Dolice had 16 saves at Tennessee this season. The Cubs expect him to compete for a big league job in 2011.

Next: After an off day Thursday, Ryan Dempster (10-10) takes on Jeff Karstens (9-8) on Friday.