Rapid Reaction: Red Sox 6, White Sox 2

CHICAGO -- The Chicago White Sox missed out on their first series sweep of the season, falling 6-2 on Wednesday to the Boston Red Sox.

How it happened: David Ortiz blooped a two-run single into left field in the first inning and it ended up being enough for Red Sox starter Clay Buchholz. Hector Santiago, working on three days of rest as he took Chris Sale's turn in the rotation, recovered to give up just those two runs and three hits with four walks over six innings. He took a soft comebacker off his pitching hand in the first inning. White Sox relievers Brian Omogrosso and Nate Jones each gave up two runs as the Red Sox put the game away late. Paul Konerko hit a ninth-inning home run.

What it means: With John Danks expected to make his first start of the season Friday, Santiago took advantage of his last chance to make an impression. If Danks returns, either Santiago or Dylan Axelrod will be bumped from the starting staff. Santiago boasts the better stuff among the two, but Axelrod has proven himself to be a steady and savvy pitcher. One of Santiago's positives actually work against him, as he has more bullpen versatility than Axelrod.

Outside the box: The White Sox didn't get much offense against Buchholz, but Alex Rios found a way to contribute once again. Rios not only drove in a run with an RBI groundout in the third inning, he extended his career-best hitting streak to 17 games with a sixth-inning single. Rios' hit streak is the longest in the American League this season.

Offbeat: The White Sox will face their third interleague opponent of the season Friday, but the first one they have played host to as the Miami Marlins will be at U.S. Cellular Field for a three-game series. Normally solid in interleague play, the White Sox are just 1-4 this season after trips to Washington and New York to face the Mets. The White Sox are 164-124 (.569) all time in interleague play, the third-best winning percentage in baseball behind the Yankees (.604) and the Angels (.575).

Up next: The White Sox will have an off day Thursday before facing the Marlins. The White Sox have yet to name a starter for Friday, but it is likely that Danks will pitch in his first major league game in more than a year, opposite the Marlins' Tom Koehler (0-2, 2.82 ERA) in the 7:10 p.m. start from U.S. Cellular Field.