Starting pitcher John Danks surrendered a career-high four home runs and fell to 0-4 with a 7.29 ERA in his last four road starts.
Paul Konerko and Adam Dunn slugged back-to-back home runs in the sixth inning but Chicago once again failed to sustain any offense. They lost all three games in Minnesota, falling 12 games below .500 for the first time since the end of the 2007 season.
Most egregious was their defense. A throwing error by second baseman Gordon Beckham and a boot by shortstop Alexei Ramirez led to a pair of unearned runs and extended two Twins innings as the home team opened a 6-1 lead.
Chicago has committed 49 errors this season and is on pace for 113. This from the team that led all of baseball in 2012 with a .988 fielding percentage.
"The one thing we were really good at last year we're just failing to do it this year," lamented manager Robin Ventura. "The home runs hurt but we weren't helping him defensively, any of the pitchers. You've got to clean that up. They scored two giving them extra outs. You just can't do it."
The White Sox have lost seven of their last eight and 17 of 21, and the effects are wearing on them.
"Across the board we're just going to have to play better," said Danks, who fell to 1-4. "I didn't do us any favors today by digging us a six-run hole or whatever it was. We're just going to have to play better as a whole. We're not saying anything we don't already know. Guys are working hard trying to make it happen. It just hasn't gone our way."
"Just bad pitches and guys did what they're supposed to do with it," Danks said. "Whether I was able to put them away or not I've still got to make my pitch. I gave a few guys some cookies."
Of note: The White Sox demoted right-handed reliever Deunte Heath to Triple-A Charlotte and will make a corresponding roster move to add another pitcher before Friday's series opener at Kansas City.
Heath walked four and was tagged for three runs, including a two-run home run to Justin Morneau, in Minnesota's 7-4 victory Wednesday night.