Rapid Reaction: Indians 6, White Sox 5

CLEVELAND -- The Chicago White Sox's losing streak reached six games after a 6-5 defeat in 10 innings Wednesday to the Cleveland Indians.

How it happened: Poised for the victory after the White Sox scored two runs in the ninth inning, the Indians added two runs of their own to force extra innings and won it in the 10th on Carlos Santana's home run against Dylan Axelrod. The White Sox appeared unchanged after getting past the stresses of the trade deadline, giving up a first-inning run after a botched rundown and trailing 3-0 after five innings. They rallied with three runs and four hits in the sixth inning to tie it. Jeff Keppinger gave them a 5-3 lead in the ninth inning on a pinch-hit, two-run single. Addison Reed gave the two runs back in the bottom of the ninth.

What it means: The bullpen has had a rough time, especially in the current series, but the White Sox have pinned their future on starting pitching, and right now that continues to be one of the few positives. Jose Quintana fought his way through a less-than-efficient 109-pitch start by giving up three runs over five innings. Despite a five-game losing streak, White Sox starters had posted a 1.51 ERA and a .197 opponents' batting average in those games, showing that the biggest issues have been on offense.

Outside the box: Quintana continued to do what he does best: take the mound and end up with nothing to show for it. The left-hander, whose record stayed at 5-3, ended his night with his major league leading 14th no-decision of the season. Things had been on the rise with a 2-1 record and a 3.04 ERA and 21 strikeouts over his past four starts, a run that began after a stretch of seven consecutive no-decisions from June 1-July 4.

Off beat: The White Sox took the rundown play to new lows in the first inning. With the Indians' Nick Swisher at first base, White Sox second baseman Gordon Beckham fielded a grounder. He kept Swisher frozen, threw to first base for the sure out and then the Sox had Swisher in a rundown. Quintana got involved by covering first base and not only fired a panicked quick throw to second base, but couldn't handle the return throw. One run scored on the play and Swisher ended up at third base when the ball went out of play.

Up next: The White Sox will send left-hander Chris Sale (6-10, 2.69 ERA) to the mound Thursday in the finale of the four-game series. The Indians will counter with right-hander Justin Masterson (12-7, 3.42) in the 11:05 a.m. CT start from Progressive Field.