Rapid Reaction: Royals 7, White Sox 2

CHICAGO -- The Chicago White Sox opened a three-game series against the Kansas City Royals with a 7-2 defeat Friday.

How it happened: White Sox starter Jose Quintana gave up hits to the first five batters of the game, and the Royals never looked back. Kansas City scored five runs in the first inning and was never threatened. Quintana finished the night having given up six runs on eight hits over six innings but settled down to retire 15 of the final 17 batters he faced. Royals starter Jeremy Guthrie gave up two runs on six hits over 5⅔ innings. White Sox leadoff man Adam Eaton reached base in all five trips to the plate with two hits and three walks.

What it means: Jose Abreu has been off the disabled list for nearly two weeks now, but the White Sox’s offense is nowhere near in sync. Eaton has been showing signs of life lately, and Gordon Beckham is hitting well, Friday notwithstanding, but production up and down the lineup isn’t what it was earlier in the season. Tyler Flowers, who was delivering hits early, is 18-for-103 with 47 strikeouts since late April. Before going 1-for-4 on Friday, Dayan Viciedo had two hits over his previous 34 at-bats. Alexei Ramirez, who is still batting over .300, has just one extra-base hit since May 23.

Outside the box: Guthrie hadn’t won a game in his previous 11 starts, but pitching against the White Sox this season hasn’t been an issue. He beat Chicago on April 4, had a no-decision against the White Sox during his winless streak and ended the winless run Friday. He entered 6-2 against the White Sox with a 2.53 ERA since joining the Royals.

Off beat: Kansas City appears to be the new Cleveland. While the Indians gave the White Sox fits last season, the Royals are now the division team that is causing issues. The White Sox do have three victories against the Royals already, one more than they had against the Indians all of last season. But the White Sox have now lost eight of their past nine home games against Kansas City going back to last season.

Up next: The White Sox will send right-hander Hector Noesi (2-4, 5.40 ERA) to the mound Saturday. The Royals will counter with left-hander Danny Duffy (3-5, 3.26) in the 1:10 p.m. start from U.S. Cellular Field.