Rapid Reaction: Cubs 6, White Sox 3

CHICAGO -- After a quick start, the Chicago White Sox couldn’t keep the momentum and fell 6-3 on Monday in the opener of the Crosstown Series at U.S. Cellular Field.

How it happened: Gavin Floyd couldn’t get off the ropes in a four-run sixth inning for the Cubs. Starlin Castro hit his second home run of the season and Carlos Pena added a three-run shot to knock Floyd from the game. Paul Konerko hit a home run for the fourth consecutive game to give him 53 interleague home runs, third all-time to Jim Thome (57) and Ken Griffey Jr. (57).

What it means: Floyd was a big piece to the White Sox’s revival about this time last season, but he has yet to get on his typical midseason roll. He has now lost four of his last five decisions dating back to May 25, although one of those losses was in relief. Just like last week’s outing at Minnesota it was one big inning that spelled doom. Floyd did not allow more than two earned runs in 12 consecutive starts last year from June 8-Aug. 7.

Outside the box: Before giving up six runs to the Cubs, Floyd had a 1.71 ERA in interleague games (73 2/3 innings). It was the lowest mark in major-league history (minimum 10 starts).

What’s next: The White Sox will send left-hander Mark Buehrle (6-5, 3.75 ERA) to the mound in the second game of the series. Buehrle is 4-0 with a 2.70 ERA over his last four home starts. The Cubs will counter with right-hander Matt Garza (3-6, 4.14) in the 7:10 p.m. start from U.S. Cellular Field.