Rapid Reaction: Orioles 6, Sox 4

BALTIMORE -- The Chicago White Sox's five-game win streak came to an end Wednesday with a 6-4 loss to the Baltimore Orioles on Nolan Reimold's walk-off home run in the 10th inning.

How it happened: Jason Frasor was tagged for Reimold's homer. Phil Humber gave up at least four runs for the fifth consecutive start but this time the White Sox offense picked him up to send the game into extra innings. The White Sox got even with a three-run seventh inning, scoring all three with two outs. Brent Morel had an opposite-field double down the right-field line for a run, while Juan Pierre had an opposite-field two-run single down the third-base line.

What it means: Playing down to the level of a team like the last-place Orioles is bound to catch up to you and it finally did in extra innings Wednesday. The loss means the White Sox missed out on a chance to move three games out of first place one week after they were 6 ½ games out. The White Sox missed out on reaching the .500 mark for the fourth time since April 16.

Outside the box: Despite a 16-5 run on the road before Wednesday’s defeat, the White Sox were hitting just .222 in that stretch.

Up next: White Sox left-hander Mark Buehrle (9-5, 3.04 ERA) will close out the series and the road trip when he takes the mound Thursday. He will be opposed by Orioles right-hander Chris Tillman (3-4, 4.85) in the 6:05 p.m. start from Camden Yards.