Rapid Reaction: A's 5, White Sox 4

Here's a quick look at the White Sox's 14-inning loss to the Oakland Athletics on Wednesday at O.co Coliseum:

How it happened: A matchup of talented young pitchers between the Sox's Chris Sale and the A's Jarrod Parker was scoreless until the sixth inning when Oakland's Josh Redick kicked off a two-run inning with an RBI double, driving home Jemile Weeks. Yoenis Cespedes followed with an RBI single and a 2-0 lead. The Sox broke through in the seventh inning when Kosuke Fukudome doubled to right-center, driving home Alex Rios with their first run. But the inning stalled when Fukudome was caught in a rundown between third and home with the Sox trailing 2-1. Paul Konerko's 400th career home run in the ninth inning tied the game 2-2 and got Sale off the hook. The White Sox squandered several chances in extra innings – including a two-on, no-out scenario in the 13th – before breaking through with a pair of runs in the 14th inning that came off Alexei Ramirez’s two-out double. Hector Santiago, however, was unable to hold the advantage. The fledgling White Sox closer gave up three runs in the bottom of the 14 – two of which came on a Yoenis Cespedes home run – to cost the South Siders a winnable game.

What it means: The White Sox return home after a 4-2 road trip which included four straight wins. Coming off an 11-strikeout victory over the Mariners, Sale got the no-decision, allowing two runs with five strikeouts in eight innings.

Outside the box: Konerko became the 48th player in major league history with 400 home runs. ... Parker, a Fort Wayne, Ind., native who grew up a White Sox fan, was the main piece acquired from the Arizona Diamondbacks in the trade of Trevor Cahill in the offseason. He allowed one earned run and struck out five in 6 1/3 innings in his second major league start and first with Oakland. ... A day after having his 11-game hitting streak snapped Rios was right back at it, going 3 for 5 to raise his batting average to .362.

What's next: The White Sox return home for a four-game series against the Boston Red Sox. Philip Humber (1-0, 0.63 ERA) makes his first start since throwing a perfect game, taking on Felix Doubront (0-0, 3.94) in the opener at 7:10 p.m. Thursday.