Rapid Reaction: Red Sox 10, White Sox 3

CHICAGO -- Here’s a quick look at the Boston Red Sox's 10-3 win over the Chicago White Sox at U.S. Cellular Field on Thursday.

How it happened: White Sox pitcher Philip Humber went from perfection to imperfection in the span of two starts. Humber threw the 21st perfect game in major league baseball in his last start against the Seattle Mariners. On Thursday, Humber followed that up by allowing a career-high nine runs. His perfect run ended with a leadoff walk in the first inning, and the Red Sox never let up. Humber allowed two runs in the first inning, five more runs, including a grand slam to Kevin Youkilis, in the fourth inning and two more runs in the fifth inning. Red Sox catcher Jarrod Saltalamacchi hit two home runs in the win. Dayan Viciedo and Paul Konerko each had two hits for the White Sox.

What it means: The White Sox have been up and down this season. Following a four-game winning streak, the White Sox have now dropped three consecutive games. They’ve had two four-game winning streaks and two three-game losing streaks this season.

Outside the box: Despite Thursday’s loss, the White Sox have been dominant over the Red Sox in recent years, winning 14 of their last 19 games against Boston. The White Sox won both series against them last season.

Up next: Starting pitcher John Danks (2-2, 5.11) will look to get himself and the White Sox back on track at 7:10 p.m. CT Friday. Daniel Bard (1-2, 4.38) will start for the Red Sox in the second game of the series.