DETROIT -- Adam Dunn hit another homer in the first inning -- and that was it for Chicago's offense.
Despite holding Detroit to 10 runs in the series, the White Sox ended up losing two of three to the defending AL Central champions.
Prince Fielder homered and Rick Porcello pitched impressively into the seventh inning to lead the Tigers to a 3-1 victory Sunday. Fielder's 432-foot shot to right-center -- his fourth of the year -- broke a 1-all tie in the third.
"We played neck and neck all weekend, but we couldn't get the one big hit we needed today to win this game and win the series," Dunn said. "That's frustrating, because we had so many opportunities, but Porcello was really good."
Porcello (3-2) allowed a run and four hits in 6 1-3 innings. Four relievers finished for the Tigers, with Jose Valverde pitching the ninth for his fifth save.
Dylan Axelrod (0-1) allowed two runs and six hits in 4 1-3 innings.
The first two games of the series were won on two-run homers in the ninth inning -- by Detroit's Jhonny Peralta on Friday night and Dunn on Saturday. The Tigers took the opener 5-4 before Chicago won the middle game 3-2.
All the runs in the finale came via the long ball, but Valverde held onto the lead this time after allowing Dunn's homer a day earlier. Valverde gave up a hit and a walk Sunday but struck out Gordon Beckham to end it.
The 26-year-old Axelrod made his first start of the season for the White Sox, part of a pitching shuffle that moved Chris Sale from starter to closer.
With a doubleheader coming up Monday at Cleveland, Chicago optioned Axelrod to Triple-A Charlotte after the game. Left-hander Eric Stults will come up from the minors to start the second game Monday, and the White Sox are also expected to add a reliever.
Axelrod struck out four and walked two.
"He pitched his guts out today," White Sox manager Robin Ventura said. "We're trying to figure out how to fill that hole in the rotation, and today was a good step for him. He made a couple mistakes against a very good offense, but he battled through a lot of things and gave us a chance to win the game."
Dunn's solo shot in the first was his ninth homer of the season, but Austin Jackson led off the bottom half with his fourth homer of the year.
Andy Dirks added a home run for Detroit in the eighth.
Detroit manager Jim Leyland altered his lineup a bit to try to boost the offense. Dirks batted second and fellow outfielder Brennan Boesch was dropped to eighth.
The Tigers had 10 hits but left 12 runners on base. Alex Avila hit into a double play with runners on first and third to end the fifth. Dirks popped out to end the sixth with runners on second and third.
With the bases loaded and two outs in the seventh, Boesch hit a routine fly.
Dirks finally added an insurance run with his homer to right.
"The key today was, if we get the pitching like we got the last couple of games, I'll be happy, because we're going to hit at some point," Leyland said. "We got some hits today, we just didn't get a lot of big ones."
Chicago outfielder Dayan Viciedo left in the seventh after being hit in the right elbow with a pitch. X-rays were negative and he is day to day.