Samuel, who has three interceptions on the season and an NFL-best 39 since 2006, will be replaced by Dominique Rodgers-Cromartie.
In his career, Samuel has just one interception against the Cowboys, but not having an elite corner on the field is a big blow for the Eagles defense.
Here's what Andy Reid said to reporters Thursday regarding Rodgers-Cromartie's play from a slot corner to an outside cornerback: "Listen, that’s where he’s played over the years. We worked him as an inside player and I thought he was getting better every week with that, but his natural spot, where he feels the most comfortable is on the outside. He’s looked good; he’s done a nice job. He doesn’t have a problem doing it."