The Big 12 has been hampered by injuries in recent weeks. Missouri running back Henry Josey, the Big 12's leading rusher, was the latest to fall. He tore his ACL, MCL and patellar tendon — a situation serious enough to put his 2012 season in question.
Texas running back Fozzy Whittaker, who scored nine touchdowns this year, also went down with a torn ACL in Saturday's victory over Missouri.
Two weeks ago, Oklahoma receiver Ryan Broyles and Texas A&M running back Christine Michael suffered torn ACLs and will miss the remainder of the season. K-State receiver/kick returner Tyler Lockett is out for the season with a lacerated kidney.
Oklahoma running back Dominique Whaley suffered a fractured ankle and Iowa State running back Shontrelle Johnson injured his neck early in the season while he was still the Cyclones' leading rusher. Texas Tech running back Eric Stephens' likely 1,000-yard season, the first in Lubbock since Ricky Williams in 1998, ended on a dislocated knee suffered in a loss to Texas A&M.
That said, there's still plenty of big talent still standing around the injury-riddled league.
Who's the most irreplaceable?
Is it Heisman contender Brandon Weeden, who leads the league in passing yards and has dished out a league-leading 31 touchdown passes at the helm of Oklahoma State's explosive offense?
Is it do-everything quarterback Robert Griffin III at Baylor, who engineered a dramatic 21-point comeback against Kansas last week to put the Bears into the postseason for the second consecutive season after a 16-year drought?
What about OSU receiver Justin Blackmon? He's likely the biggest talent in Stillwater, and the only game he missed in the past two seasons was the one time the Cowboys were held under 30 points, a 24-14 victory over Kansas State last October.
What about the nation's leader in rushing touchdowns, K-State quarterback Collin Klein? With Josey down, he's now the Big 12's leading rusher, and only two players in the FBS have more carries.
Oklahoma quarterback Landry Jones is the last man standing at OU, playing without his leading receiver, Broyles, and leading rusher, Whaley. What would happen to the Sooners if he went down?
So, who's the most irreplaceable? Vote in our poll.