Hamilton stroked a three-run homer and Cruz hit a solo shot in a game against Colorado Springs.
The struggling Rangers offense, which has scored just two runs the last two nights, is missing their biggest sluggers.
Hamilton (broken arm) and Cruz (quadriceps) could return from the DL on Monday if all goes well with their rehab efforts.
"I wish they homered in Philly," manager Ron Washington said when told of the home runs. "There's light at the end of the tunnel. I'm impressed with my starting pitching. We just got to get healthy offensively and get people in spots where they belong and get Hamilton and Cruz back in there and have a lineup we thought we would have and go from there."