The teams going in opposite directions will meet Sunday in London's Wembley Stadium in the second of two NFL games being played in the United Kingdom this season.
The 49ers (5-2) have won four games in a row -- and scored at least 31 points in each of those games -- since starting the season 1-2. The Jaguars are 0-7 and are the first team since the 1984 Houston Oilers to lose their first seven games by double digits.
That makes Sunday's game look like a giant mismatch, yet the Jaguars were 28-point underdogs to the Denver Broncos two weeks ago but lost by only 16 points -- and trailed by just two at halftime.
ESPN.com Jaguars reporter Michael DiRocco and 49ers reporter Bill Williamson break down the matchup:
DiRocco: The 49ers used the read-option the most they have all season against Tennessee in Week 7. Will that be a bigger part of the offense again as the season progresses?
Williamson: Mike, I think it is going to be a week-to-week situation. The 49ers used the read-option seven times last week after using it a total of nine in the first six games. The 49ers saw they could exploit Tennessee's defense using it. I think we will see it again, but probably in more challenging games and only in certain situations, when the 49ers are confident it will work. We could maybe see it some in London, but I have a feeling it will be more like the first six weeks of the season.
Mike, if the 49ers do run a lot of read-option offense, do you think the Jaguars can handle it?
DiRocco: Probably not. The Jaguars are last in the NFL in rushing defense (153.3 yards per game) and have given up a league-high nine rushing touchdowns. The defense's biggest problem against the rush is that it has given up a lot of explosive plays. Jacksonville has allowed an NFL-worst 10 rushing plays of 20 or more yards. Stopping the read-option is assignment football and the Jaguars' ends have not been as disciplined as needed. For example, Oakland's Terrelle Pryor ran for 50 yards in Week 2, including a 27-yard run in which the entire defensive front bit on the inside fake.
Bill, the Jaguars have had trouble with tight ends all season and now they face Vernon Davis. Who is the last team that's shut him down how?
Williamson: Davis hurt his hamstring late in the Seattle game in Week 2. He was pretty well shut down in that game before getting hurt. He missed Week 3 against the Colts and then came back against the Rams. He's been good and he is healthy. If the Jaguars have trouble against tight ends, the 49ers will exploit it. Davis and quarterback Colin Kaepernick have a great chemistry going this season. The 49ers' coaching staff is great at exploiting weaknesses.
Mike, do you seeing this being a big problem for Jacksonville?
DiRocco: Absolutely. Tight ends have combined to catch 42 passes for 401 yards and five touchdowns against Jacksonville this season. Depending on the defense called, the Jaguars will either have a safety or linebacker on the tight end. At times, the job has fallen to middle linebacker Paul Posluszny, who is very good against the run but not fast or quick enough in pass coverage. The Jaguars won't use the approach New England did against New Orleans standout Jimmy Graham -- the Patriots put their best corner, Aqib Talib, on him -- so I'd expect Davis to have chances to exploit some matchups with linebackers on Sunday.
Speaking of exploitation, the Anquan Boldin trade looked like a steal in Week 1. How is it regarded now?
Williamson: Still, unabashed thievery. Sure, Boldin had 13 catches in the first week and a combined 21 catches in the following six. But the 49ers would be in trouble without Boldin. He had three circus catches at Tennessee and he's been the team's only reliable wide receiver with Michael Crabtree and Mario Manningham out. The 49ers would not be 5-2 without Boldin.
Mike, do you think the Jaguars will keep him in check Sunday?
DiRocco: The Jaguars have done a solid job the past two weeks of playing umbrella coverage and making sure they don't give up deep throws. That does leave the short and intermediate routes open, though, and that's where Boldin thrives. He's a physical receiver and the Jaguars don't yet have the kind of personnel to match up with him. Coach Gus Bradley wants to build a secondary similar to the one he helped build in Seattle, which includes big, physical corners. The Jaguars still have work to do there, although rookie third-round pick Dwayne Gratz (5-foot-11, 201 pounds) is finally back from his high-ankle sprain.