Not only will the team be missing Kobe Bryant, Xavier Henry and Kent Bazemore -- all of whom had their seasons shut down prematurely because of injuries -- Steve Nash (hamstring), Pau Gasol (vertigo) and Chris Kaman (right calf strain) are all unlikely to play against the Golden State Warriors on Friday.
Nash, who said he was "probably" finished for the season after feeling a "bite" in his hamstring in the Lakers' 145-130 loss to the Houston Rockets on Tuesday, has shown signs of improvement.
"Steve said he feels a lot better," Lakers coach Mike D'Antoni said after practice Thursday. "I would say doubtful for tomorrow, but maybe for the rest of the year."
The Lakers have three games remaining after Friday -- their final home game Sunday against the Memphis Grizzlies, followed by road games Monday in Utah and Wednesday in San Antonio.
Pau Gasol, who told ESPNLosAngeles.com after the Rockets game he was "unlikely" to play again this season, worked out at the practice facility Thursday, and has not been officially ruled out yet.
"He'll play if he can, but he has to be medically cleared," D'Antoni said of Gasol, who has missed seven of the last eight games.
Meanwhile, Kaman has missed the Lakers' last four games after saying he "landed funny" after going airborne in the first half of the Lakers' 124-112 loss to the Portland Trail Blazers on April 1.
"I've never really had an injury like this," Kaman said. "I've rolled my ankle and messed my back up, but the calf strain is kind of a weird thing. I'm trying to push myself a little bit, hopefully I can try to play in the last two games. We'll see. I don't know if that's possible or not."