Can Tannehill lead the Dolphins to their second road win of the season? The Dolphins' defense looked dominant, producing six sacks and three interceptions. If Tannehill plays well and the defense rattles Luck, that could be a formula for an upset.
Or will the Colts be too much at home? Indianapolis is tough to beat inside the dome at Lucas Oil Stadium. The Colts also beat the Dolphins, 23-20, in a well-played game in 2012. Will Indianapolis beat Miami at home for the second year in a row?
Using our SportsNation poll, vote on the winner of Sunday's Dolphins-Colts matchup. You can also share your thoughts in the comment section below or hit me up via Twitter @JamesWalkerNFL.