Big East predictions: Week 5

My turn to predict the future.

Buffalo at Connecticut, noon ET, Big East Network/ESPN3: Another MAC upset? Unlikely. The Bulls just don't possess the threats that Western Michigan was able to utilize early last week against the Huskies. UConn's defense should have a field day against an overmatched offense and Chandler Whitmer and his offense will look to play with some of the same sense of urgency that they did late in last week's loss. UConn 20, Buffalo 3.

Andrea's pick: UConn 23, Buffalo 17

Virginia Tech at Cincinnati (in Landover, Md.), 3:30 ET, ESPNU/WatchESPN: The Bearcats are treating this contest like a road game, as they should. We still don't know too much about them yet, and they probably don't either after two bye dates through the season's first four weeks. But the Hokies have struggled up front and will have their hands full with a Cincinnati defense that has recorded eight sacks through its first two contests. Cincinnati 20, Virginia Tech 17

Andrea's pick: Cincinnati 24, Virginia Tech 23

No. 4 Florida State at South Florida, 6 ET, ESPN: A press release from FSU earlier this week was headlined "Seminoles Aim to Clean up Mistakes Against USF." What would USF's say if the Bulls were as harsh on themselves? This team has lost two in a row, first by giving the ball away four times to Rutgers, then by committing 11 penalties, turning the ball over two more times and missing an extra point in an upset loss at Ball State. The Seminoles committed 11 penalties themselves last week but still put up 49 on then-No. 10 Clemson. FSU 42, USF 10

Andrea's pick: FSU 40, USF 17

No. 19 Louisville at Southern Miss, 8 ET, CBS Sports Network: Coach Charlie Strong challenged his Cardinals this week to keep pushing if they want to make the jump from good to great this season. Great would mean a run at a Big East title, something the 4-0 squad would likely fall short of with performances like the ones it has put forth over the past six quarters in too-close-for-comfort wins over FIU and UNC. The team needs to get more pressure on the quarterback, and the Golden Eagles may just be the perfect opponent for the Cardinals to shore up some loose ends against before entering conference play. Louisville 38, Southern Miss 10

Andrea's pick: Louisville 35, Southern Miss 13