A handful of statistical nuggets from the Patriots’ season-opening 23-21 victory over the Bills:
Tight ends are quiet: Tom Brady was 1-of-3 for 5 yards and an interception when targeting tight ends on Sunday, the second time since the start of 2010 (Rob Gronkowski's first season) that Patriots tight ends have not caught multiple passes in a game.
Slot receiver still Brady’s favorite: Danny Amendola had 10 receptions for 104 yards and nine first downs in his Patriots debut. Since the start of 2008, Wes Welker -- whom Amendola essentially replaced as the team’s slot receiver -- had at least nine first downs in a game twice in 77 games.
Manuel uses shotgun in debut: After missing two preseason games with minor knee surgery, EJ Manuel used the shotgun effectively to limit unnecessary movement in his debut. Manuel was 18-for-25 for 150 yards from the shotgun, including both of his touchdown passes. The Patriots put Manuel under duress on just 6 of 30 drop-backs Sunday.