Here are the key numbers and other trivia from the big matches on Day 3 of the Australian Open 2017.
Federer betters record against Americans
With his second-round 7-5, 6-3, 7-6 (3) win against Noah Rubin, Roger Federer improves his record to 34-1 in Grand Slams against Americans, and also improves to 26-1 in Slams against qualifiers. The lone loss came against Andre Agassi at the US Open in 2001 (he's won 29 straight since that loss).
Federer has now reached the third round in all 18 of his appearances at the Australian Open.
Parallels between Federer and Rubin:
Both earned their first career major match win at the Australian Open - Federer defeated Michael Chang in 2000, Rubin beat Benoit Paire last year
Both are former boys' singles champions at Wimbledon - Federer won in 1998, Rubin in 2014
Isner falters in the fifth. Again.
John Isner has a thing for really, really long matches. Here's a look at some of his notable five-set encounters, many of which he has lost:
2017 Aus Open: lost to Mischa Zverev 7-6 (4), 7-6 (4), 4-6, 6-7 (9), 7-9
2016 Wimbledon: lost to Jo-Wilfried Tsonga 6-7 (3), 3-6, 7-6 (5), 6-2, 19-17
2015 Wimbledon: lost to Marin Cilic 7-6 (4), 6-7 (6), 6-4, 6-7 (4) 12-10
2015 Davis Cup 1R: lost to James Ward 6-7 (4), 5-7, 6-3, 7-6 (3), 15-13
2013 French Open: lost to Tommy Haas 7-5, 7-6 (4), 4-6, 6-7 (10), 10-8
2012 French Open: lost to Paul-Henri Mathieu 6-7 (2), 6-4, 6-4, 3-6, 18-16
2010 Wimbledon: def. Nicolas Mahut 6-4, 3-6, 6-7 (7), 7-6 (3), 70-68
Since winning the 2010 Wimbledon first-round encounter 70-68 in the fifth (the longest tennis match ever), Isner's record is a poor 4-14 in five-set matches. His career record in five setters stands at: 3-2 in the first five and 4-14 in the last 18.
Mischa Zverev, on the other hand, earned his first career five-set victory (he was 0-3 coming in). The Isner-Zverev match was the second-longest of the tournament at four hours and 6 minutes.
Kerber wins on birthday, eyes Slam age record
Angelique Kerber defeated fellow German Carina Witthoeft 6-2, 6-7 (3), 6-2, taking her Grand Slam record against fellow Germans to a perfect 7-0.
No woman has ever lost before the third round in their first major as World No. 1 and Kerber ensured she wouldn't be the first on that list, requiring three sets for the second straight match after her first-round match against Ukraine's Lesia Tsurenko also went the distance.
With both of her Grand Slam titles coming after her 28th birthday, Kerber is looking to become the first woman in the Open Era to win her first three Grand Slam titles after her 28th birthday. Kerber turned 29 years old on Wednesday, January 18.
Stats from ESPN Statistics and Information Group